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Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease

Abstract:

Corticosteroid resistance is a major barrier to the effective treatment of chronic obstructive pulmonary disease (COPD). Oxidative stress from cigarette smoke and chronic inflammation is likely to induce this corticosteroid insensitivity. Quercetin is a polyphenol that has been reported to be an active oxygen scavenger as well as a functional adenosine monophosphate-activated protein kinase (AMPK) activator.


The aim of this study was to investigate the effect of quercetin on c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Role:
Author
ORCID:
0000-0002-2669-2223
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
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National Institute for Health Research More from this funder
Banyu Life Science Foundation International More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Experimental Lung Research Journal website
Volume:
43
Issue:
9-10
Pages:
417-425
Publication date:
2017-12-11
Acceptance date:
2017-10-14
DOI:
EISSN:
1521-0499
ISSN:
0190-2148
Pubs id:
pubs:826137
URN:
uri:58b224c9-5269-4621-a7f6-00a72db60d88
UUID:
uuid:58b224c9-5269-4621-a7f6-00a72db60d88
Local pid:
pubs:826137

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