Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice.

Journal article

Resistin is an adipokine that contributes to insulin resistance in mice. In humans, however, studies investigating the link between resistin and metabolic disease are conflicting. Further complicating the matter, human resistin is produced mainly by macrophages rather than adipocytes. To address this important issue, we generated mice that lack adipocyte-derived mouse resistin but produce human resistin in a pattern similar to that found in humans, i.e., in macrophages (humanized resistin mic...

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Authors: Qatanani, M; Szwergold, N; Greaves, D; Ahima, R; Lazar, M

• Publication status: Published
• Journal: Journal of clinical investigation
• Volume: 119
• Issue: 3
• Pages: 531-539
• Publication date: 2009-03-01
• DOI: 10.1172/jci37273
• EISSN: 1558-8238
• ISSN: 0021-9738
• Language: English
• Keywords: Lipolysis; Lipid Metabolism; Macrophages; Cytokines; Mice, Knockout; Antigens, CD; Inflammation; Insulin Resistance; Lipoprotein Lipase; Signal Transduction; Gene Expression; Antigens, Differentiation, Myelomonocytic; Mice, Inbred C57BL; Male; Insulin; Mice, Transgenic; Humans; Insulin Receptor Substrate Proteins; Cell Movement; Muscle, Skeletal; Protein Kinase C; Glucose Tolerance Test; Animal Structures; Animals; Resistin; Blood Glucose; Restless Legs Syndrome; Dietary Fats; Isoenzymes; Mice; Lipids; Adipose Tissue, White; Glucose Clamp Technique