Pleiotropic effect of somatic mutations in the E2F subunit DP-1 gene in human cancer.

Journal article

Transcription factor E2F-1 and its interaction with pRb provide a key point of control in cell proliferation. E2F-1 participates in both cell cycle progression and apoptosis, and in cells exists with a DP dimerization partner protein, the most prominent being DP-1. By mining the tumor tissue and cancer cell line encyclopedia genomic databases, we identified the first somatic mutations in the DP-1 gene and describe 53 distinct mutation events here. The mutations are mostly missense mutations, ...

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Authors: Munro, S; Oppermann, U; La Thangue, N

• Publication status: Published
• Publisher: Nature Publishing Group
• Journal: Oncogene
• Volume: 33
• Issue: 27
• Pages: 3594-3603
• Publication date: 2014-07-01
• DOI: 10.1038/onc.2013.316
• EISSN: 1476-5594
• ISSN: 0950-9232
• Language: English
• Keywords: Humans; Protein Structure, Quaternary; Amino Acid Sequence; Genetic Pleiotropy; Retinoblastoma Protein; Mutation; E2F1 Transcription Factor; Protein Multimerization; Phosphoproteins; Transcription Factor DP1; Apoptosis; Cell Line, Tumor; Models, Molecular; Protein Subunits; Molecular Sequence Data