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Journal article

FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration

Abstract:

Aberrant centrosome organisation with ensuing alterations of microtubule nucleation capacity enables tumour cells to proliferate and invade despite increased genomic instability. CEP192 is a key factor in the initiation process of centrosome duplication and in the control of centrosome microtubule nucleation. However, regulatory means of CEP192 have remained unknown. Here, we report that FBXL13, a binding determinant of SCF (SKP1-CUL1-F-box)-family E3 ubiquitin ligases, is enriched at centros...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embr.201744799

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Richter, C More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Schäffer, I More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
ORCID:
0000-0002-9715-5951
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Funding agency for:
Kessler, BM
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Funding agency for:
Kessler, BM
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Funding agency for:
D'Angiolella, V
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Grant:
MC_PC_12007 to V. D’A.
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Reports Journal website
Volume:
19
Issue:
3
Pages:
Article: e44799
Publication date:
2018-01-18
Acceptance date:
2017-12-20
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Pubs id:
pubs:821295
URN:
uri:58a4b02d-d9d8-4d2a-9cf5-44f7d5e4d69f
UUID:
uuid:58a4b02d-d9d8-4d2a-9cf5-44f7d5e4d69f
Local pid:
pubs:821295
Language:
English
Keywords:

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