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Microfluidic chambers using fluid walls for cell biology

Abstract:

Many proofs of concept have demonstrated the potential of microfluidics in cell biology. However, the technology remains inaccessible to many biologists, as it often requires complex manufacturing facilities (such as soft lithography) and uses materials foreign to cell biology (such as polydimethylsiloxane). Here, we present a method for creating microfluidic environments by simply reshaping fluids on a substrate. For applications in cell biology, we use cell media on a virgin Petri dish over...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1073/pnas.1805449115

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
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Funding agency for:
Castrejón-Pita, AA
Iota Sciences Ltd More from this funder
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Grant:
Impact Acceleration Account to P.R.C. and E.J.W.
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
115
Issue:
26
Pages:
E5926-E5933
Publication date:
2018-06-12
Acceptance date:
2018-06-12
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:857215
URN:
uri:589e7684-ec68-493a-b0af-25f9b2f35de9
UUID:
uuid:589e7684-ec68-493a-b0af-25f9b2f35de9
Local pid:
pubs:857215

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