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Journal article

Characterization of HIV-1-specific cytotoxic T lymphocytes expressing the mucosal lymphocyte integrin CD103 in rectal and duodenal lymphoid tissue of HIV-1-infected subjects.

Abstract:

Acute HIV-1 infection depletes CD4(+) T cells in gut-associated lymphoid tissue (GALT). The failure of containment of local viral replication, and consequent CD4(+) T cell depletion, might be due to delayed mobilization of effector CD8(+) T cells or absence of functioning HIV-1-specific CD8(+) T cell effectors within GALT. No studies have addressed human intestinal HIV-1-specific CD8(+) T cell functions. We sought to determine whether functional HIV-1-specific CTL were present in GALT and whe...

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Publication status:
Published

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Publisher copy:
10.1006/viro.2000.0299

Authors


Shacklett, BL More by this author
Beadle, TJ More by this author
Pacheco, PA More by this author
Grendell, JH More by this author
Haslett, PA More by this author
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Journal:
Virology
Volume:
270
Issue:
2
Pages:
317-327
Publication date:
2000-05-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:5891c887-6cb5-44bb-a40f-5c0da6db1dec
Source identifiers:
6804
Local pid:
pubs:6804

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