Effect of 5-hydroxy-L-tryptophan on the release of 5-HT in rat hypothalamus in vivo as measured by microdialysis.

Journal article

The effect of systemic administration of the 5-HT precursor, 5-hydroxy-L-tryptophan (5-HTP) on the release of 5-HT in the lateral hypothalamus of the chloral hydrate-anaesthetized rat in vivo was examined using brain microdialysis. Administration of 5-HTP caused an immediate increase of 5-HT in dialysates, which was long lasting (greater than or equal to 140 min) and dose-dependent (30-100 mg/kg i.p.). When calcium was omitted from the perfusion medium, thereby limiting exocytosis, levels of ...

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Authors: Gartside, SE; Cowen, P; Sharp, T

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 31
• Issue: 1
• Pages: 9-14
• Publication date: 1992-01-01
• DOI: 10.1016/0028-3908(92)90154-h
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: 5-Hydroxytryptophan; Serotonin; Dialysis; Tetrahydronaphthalenes; Male; Exocytosis; 8-Hydroxy-2-(di-n-propylamino)tetralin; Chromatography, High Pressure Liquid; Rats; Calcium; Hypothalamus; Dendrites; Animals; Rats, Inbred Strains