Thesis icon

Thesis

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models

Abstract:

The cerebellar ataxias are a heterogeneous group of incurable disorders that are characterised by progressive dysfunction and degeneration of Purkinje cells. Although numerous causative genes have been identified, the underlying pathogenic mechanisms remain incompletely understood, due to the limited availability of human brain tissue and the lack of reliable disease models. Accumulating evidence has suggested that subtypes of autosomal dominant ataxias (SCAs) are likely to be caused by sh...

Expand abstract

Actions


Authors


More by this author
Role:
Author, Copyright Holder

Contributors

Department:
DPAG, University of Oxford
Role:
Supervisor
Department:
NDCN, University of Oxford
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP