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Thesis

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models

Abstract:

The cerebellar ataxias are a heterogeneous group of incurable disorders that are characterised by progressive dysfunction and degeneration of Purkinje cells. Although numerous causative genes have been identified, the underlying pathogenic mechanisms remain incompletely understood, due to the limited availability of human brain tissue and the lack of reliable disease models. Accumulating evidence has suggested that subtypes of autosomal dominant ataxias (SCAs) are likely to be caused by sh...

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Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:588ea958-3207-4509-9b13-b7843b4752c7
Deposit date:
2019-05-24

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