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Hypoactivation of the ventral and dorsal striatum during reward and loss anticipation in antipsychotic and mood stabilizer-naive bipolar disorder.

Abstract:

Increased activity within known reward-processing neurocircuitry (eg, ventral striatum, VS) has been reported among medicated individuals with bipolar disorder (BD) I and II. However, such findings are confounded by the potential ameliorative effects of mood-stabilizing and antipsychotic medications on neural activations. This study tests the hypothesis that a pathophysiological locus of alterations in reward processing is present within the striatum in antipsychotic and lithium-naive individ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/npp.2014.215

Authors


Worhunsky, PD More by this author
Rogers, RD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Publisher:
Nature Publishing Group: Publisher's website
Journal:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Journal website
Volume:
40
Issue:
3
Pages:
658-666
Publication date:
2015
DOI:
EISSN:
1740-634X
ISSN:
0893-133X
URN:
uuid:58888366-c47c-4778-a6b8-a9b77f61b44d
Source identifiers:
481498
Local pid:
pubs:481498
Language:
English

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