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Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

Abstract:

Cannabinoid receptor 2 (CB2) agonists provide the potential for treating chronic pain states without CNS effects associated with CB1 receptor activation. Animal models suggest that they act mainly via non-neuronal cells, possibly inhibition of inflammatory cells in the periphery or CNS, or via release of beta-endorphin; however, the clinical relevance and mechanism of analgesic action is uncertain. Here, we demonstrate colocalisation of CB2 with CB1 and the capsaicin receptor TRPV1 in human d...

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Publication status:
Published

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Publisher copy:
10.1016/j.pain.2008.06.007

Authors


Sanchez-Herrera, D More by this author
Yiangou, Y More by this author
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Journal:
Pain
Volume:
138
Issue:
3
Pages:
667-680
Publication date:
2008-09-05
DOI:
EISSN:
1872-6623
ISSN:
0304-3959
URN:
uuid:58863255-bf0e-4fbd-ab84-207435f2701a
Source identifiers:
34348
Local pid:
pubs:34348

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