Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

Journal article

Cannabinoid receptor 2 (CB2) agonists provide the potential for treating chronic pain states without CNS effects associated with CB1 receptor activation. Animal models suggest that they act mainly via non-neuronal cells, possibly inhibition of inflammatory cells in the periphery or CNS, or via release of beta-endorphin; however, the clinical relevance and mechanism of analgesic action is uncertain. Here, we demonstrate colocalisation of CB2 with CB1 and the capsaicin receptor TRPV1 in human d...

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Authors: Anand, U; Otto, W; Sanchez-Herrera, D; Facer, P; Yiangou, Y

• Publication status: Published
• Journal: Pain
• Volume: 138
• Issue: 3
• Pages: 667-680
• Publication date: 2008-09-01
• DOI: 10.1016/j.pain.2008.06.007
• EISSN: 1872-6623
• ISSN: 0304-3959
• Language: English
• Keywords: Female; Humans; Adolescent; Cricetulus; Receptor, Cannabinoid, CB2; Neural Inhibition; Cannabinoids; Child; Sensory Receptor Cells; Capsaicin; Cells, Cultured; Cricetinae; Adult; Male; Animals; Aged; CHO Cells; Middle Aged