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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: A systematic review and meta-analysis of individual patient data

Abstract:

Background

Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual patient clinical data meta-analysis was undertaken to identify the determinants of gametocyte carriage and the comparative effects of four...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1186/s12916-016-0621-7

Authors


Abdulla, S More by this author
D'Alessandro, U More by this author
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Bill and Melinda Gates Foundation More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Medicine Journal website
Volume:
14
Issue:
1
Publication date:
2016-05-05
DOI:
ISSN:
1741-7015
Pubs id:
pubs:625323
URN:
uri:5881a62f-074c-435f-ba1e-2cc30ec52159
UUID:
5881a62f-074c-435f-ba1e-2cc30ec52159
Local pid:
pubs:625323

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