Journal article icon

Journal article

T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics

Abstract:

‘Targeted’ or ‘biological’ cancer treatments rely on differential gene expression between normal tissue and cancer, and genetic changes that render tumour cells especially sensitive to the agent being applied. Problems exist with the application of many agents as a result of damage to local tissues, tumour evolution and treatment resistance, or through systemic toxicity. Hence, there is a therapeutic need to uncover specific clinical targets which enhance the efficacy of cancer treatment whil...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41419-018-1131-7

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
ORCID:
0000-0001-9437-0253
Ashton, TM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Pirovano, G More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
ORCID:
0000-0003-3072-909X
Publisher:
Springer Nature Publisher's website
Journal:
Cell Death and Disease Journal website
Volume:
9
Pages:
Article: 1089
Publication date:
2018-10-24
Acceptance date:
2018-10-08
DOI:
EISSN:
2041-4889
Pubs id:
pubs:936580
URN:
uri:586e4a8d-e902-4d11-941e-ee361b3e3d8f
UUID:
uuid:586e4a8d-e902-4d11-941e-ee361b3e3d8f
Local pid:
pubs:936580
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP