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Journal article

Guidelines for pre-clinical animal and cellular models of MuSK-myasthenia gravis.

Abstract:

Muscle-specific tyrosine kinase (MuSK) autoantibodies are the hallmark of a form of myasthenia gravis (MG) that can challenge the neurologist and the experimentalist. The clinical disease can be difficult to treat effectively. MuSK autoantibodies affect the neuromuscular junction in several ways. When added to muscle cells in culture, MuSK antibodies disperse acetylcholine receptor clusters. Experimental animals actively immunized with MuSK develop MuSK autoantibodies and muscle weakness. Wea...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Academic Press Inc. Publisher's website
Journal:
Experimental Neurology Journal website
Volume:
270
Pages:
29–40
Publication date:
2015-08-05
DOI:
EISSN:
1090-2430
ISSN:
0014-4886
URN:
uuid:586c00e6-f300-4fa5-b2bd-f5ec5b1a62a7
Source identifiers:
503147
Local pid:
pubs:503147

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