Journal article
Guidelines for pre-clinical animal and cellular models of MuSK-myasthenia gravis.
- Abstract:
-
Muscle-specific tyrosine kinase (MuSK) autoantibodies are the hallmark of a form of myasthenia gravis (MG) that can challenge the neurologist and the experimentalist. The clinical disease can be difficult to treat effectively. MuSK autoantibodies affect the neuromuscular junction in several ways. When added to muscle cells in culture, MuSK antibodies disperse acetylcholine receptor clusters. Experimental animals actively immunized with MuSK develop MuSK autoantibodies and muscle weakness. Wea...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/j.expneurol.2014.12.013
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Bibliographic Details
- Publisher:
- Academic Press Inc. Publisher's website
- Journal:
- Experimental Neurology Journal website
- Volume:
- 270
- Pages:
- 29–40
- Publication date:
- 2015-08-01
- DOI:
- EISSN:
-
1090-2430
- ISSN:
-
0014-4886
- Source identifiers:
-
503147
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:586c00e6-f300-4fa5-b2bd-f5ec5b1a62a7
- Local pid:
- pubs:503147
- Deposit date:
- 2015-03-14
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2015
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