Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta.

Journal article

Studies in mice have suggested that the placenta is protected from immune rejection by maternal T cells by means of localised indoleamine 2,3-dioxygenase dependent depletion of tryptophan. To determine whether such mechanisms might operate in the human placenta, we have studied the physiological importance of human placental indoleamine 2,3-dioxygenase immunohistochemically and functionally. Indoleamine 2,3-dioxygenase is detectable immunohistochemically from day 6 human blastocysts and there...

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Authors: Kudo, Y; Boyd, C; Spyropoulou, I; Redman, C; Takikawa, O

• Publication status: Published
• Journal: Journal of reproductive immunology
• Volume: 61
• Issue: 2
• Pages: 87-98
• Publication date: 2004-04-01
• DOI: 10.1016/j.jri.2003.11.004
• EISSN: 1872-7603
• ISSN: 0165-0378
• Language: English
• Keywords: Humans; Immunohistochemistry; Pregnancy; Cell Division; Culture Techniques; Extraembryonic Membranes; Macrophages; Leukocytes, Mononuclear; Blastocyst; Gene Expression Regulation, Developmental; Tryptophan Oxygenase; T-Lymphocytes; Lymphocyte Activation; Antiviral Agents; Interferon-gamma; Placenta; Female; Maternal-Fetal Exchange; Tryptophan