Mitotic exit in two dimensions.

Journal article

Metaphase of mitosis is brought about in all eukaryotes by activation of cylin-dependent kinase (Cdk1), whereas exit from mitosis requires down-regulation of Cdk1 activity and dephosphorylation of its target proteins. In budding yeast, the completion of mitotic exit requires the release and activation of the Cdc14 protein-phosphatase, which is kept inactive in the nucleolus during most of the cell cycle. Activation of Cdc14 is controlled by two regulatory networks called FEAR (Cdc fourteen ea...

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Authors: Tóth, A; Queralt, E; Uhlmann, F; Novák, B

• Publication status: Published
• Journal: Journal of theoretical biology
• Volume: 248
• Issue: 3
• Pages: 560-573
• Publication date: 2007-10-01
• DOI: 10.1016/j.jtbi.2007.06.014
• EISSN: 1095-8541
• ISSN: 0022-5193
• Language: English
• Keywords: Protein Tyrosine Phosphatases; Cell Cycle Proteins; Endopeptidases; Down-Regulation; Ubiquitin-Protein Ligase Complexes; Cyclin B; Saccharomyces cerevisiae Proteins; Phosphorylation; Cyclin-Dependent Kinases; Models, Biological; Mitosis; Anaphase; CDC2 Protein Kinase; Enzyme Activation; Fungal Proteins; Mathematics; Saccharomycetales