Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

Journal article

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma fracture in 31,016 individuals with a history of fracture (cases) and 102,444 controls. We ident...

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Authors: Estrada, K; Styrkarsdottir, U; Evangelou, E; Hsu, Y; Duncan, E

• Publication status: Published
• Journal: Nature genetics
• Volume: 44
• Issue: 5
• Pages: 491-501
• Publication date: 2012-05-01
• DOI: 10.1038/ng.2249
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Lumbar Vertebrae; European Continental Ancestry Group; Quantitative Trait Loci; Intercellular Signaling Peptides and Proteins; Computational Biology; Genetic Predisposition to Disease; Phosphoproteins; Mitochondrial Membrane Transport Proteins; Polymorphism, Single Nucleotide; Gene Expression Profiling; Genome-Wide Association Study; Low Density Lipoprotein Receptor-Related Protein-5; Glycoproteins; Male; Bone Density; Femur Neck; Risk Factors; Humans; Fractures, Bone; Osteoporosis; Extracellular Matrix Proteins; Spectrin; Female; Genotype