Journal article icon

Journal article

Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study.

Abstract:

OBJECTIVE: Several lines of evidence suggest that estrogens influence the development of osteoarthritis (OA). The aim of this study was to explore the association of two common polymorphisms within the aromatase (CYP19A1) and estrogen receptor (ER) alpha (ESR1) genes with severe OA of the lower limbs. METHODS: The rs1062033 (CYP19A1) and rs2234693 (ESR1) single nucleotide polymorphisms were genotyped in 5528 individuals (3147 patients with severe hip or knee OA, and 2381 controls) from four ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.joca.2010.04.002

Authors


Riancho, JA More by this author
García-Ibarbia, C More by this author
Gravani, A More by this author
Rodríguez-Fontenla, C More by this author
Expand authors...
Journal:
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Volume:
18
Issue:
7
Pages:
927-933
Publication date:
2010-07-05
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
URN:
uuid:5856ff3e-a7a0-4432-81b1-c2a68f2a51d1
Source identifiers:
107315
Local pid:
pubs:107315

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP