- There is a necessity to better characterize uveal melanoma (UM) tumors according to their metastasis potential at an early stage. In this study we report the identification of potential biomarkers by a combination of proteomics-related approaches: the characterization of UM cell secretomes, the analysis of UM autoantibodies, and the differential depleted serum proteome analysis. We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers.
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher copy:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal of Proteome Research Journal website
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- Source identifiers:
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- Copyright holder:
- American Chemical Society
- Copyright date:
- © 2007 American Chemical Society. The final version is available online from the American Chemical Society at: [10.1021/pr070021t]
Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.
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