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Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.

Abstract:
There is a necessity to better characterize uveal melanoma (UM) tumors according to their metastasis potential at an early stage. In this study we report the identification of potential biomarkers by a combination of proteomics-related approaches: the characterization of UM cell secretomes, the analysis of UM autoantibodies, and the differential depleted serum proteome analysis. We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/pr070021t

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Oxford Glycobiology Institute Endowment More from this funder
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Proteome Research Journal website
Volume:
6
Issue:
7
Pages:
2802-2811
Publication date:
2006-12-23
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
URN:
uuid:584a9cce-e1bc-4f7e-beb6-1995f5daf826
Source identifiers:
100277
Local pid:
pubs:100277

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