Journal article icon

Journal article

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.

Abstract:

Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylation sequons, NX(S/T). These potential glycosylation sites are introduced by somatic mutation and are lymphoma-specific, pointing to their involvement in tumor pathogenesis. Analysis of the V region sugars from lymphoma-derived IgG/IgM reveals ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m602690200

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Expand authors...
Journal:
The Journal of biological chemistry
Volume:
282
Issue:
10
Pages:
7405-7415
Publication date:
2007-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:5843d48f-ca3c-4b3d-8613-efd19ca750b6
Source identifiers:
100089
Local pid:
pubs:100089

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP