Journal article
Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.
- Abstract:
-
Expression of surface immunoglobulin appears critical for the growth and survival of B-cell lymphomas. In follicular lymphoma, we found previously that the Ig variable (V) regions in the B-cell receptor express a strikingly high incidence of N-glycosylation sequons, NX(S/T). These potential glycosylation sites are introduced by somatic mutation and are lymphoma-specific, pointing to their involvement in tumor pathogenesis. Analysis of the V region sugars from lymphoma-derived IgG/IgM reveals ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 282
- Issue:
- 10
- Pages:
- 7405-7415
- Publication date:
- 2007-03-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
100089
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:100089
- UUID:
-
uuid:5843d48f-ca3c-4b3d-8613-efd19ca750b6
- Local pid:
- pubs:100089
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2007
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