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Journal article

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.

Abstract:

The chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene in the region, since it contains the most disease-associated single-nucleotide polymorphisms (SNPs), as well as an imunoreceptor tyrosine-based activation motif. However, here we report that intron 19 of CLEC16A, containing the most autoimmune disease-associated SNPs, appears to behave as a re...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddr468

Authors


Davison, LJ More by this author
Wallace, C More by this author
Cooper, JD More by this author
Wilson, NK More by this author
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Journal:
Human molecular genetics
Volume:
21
Issue:
2
Pages:
322-333
Publication date:
2012-01-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:583cc6d6-95b1-4ed3-bea2-b0eee91dee89
Source identifiers:
445325
Local pid:
pubs:445325

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