Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria.

Journal article

On the western border of Thailand, in an area endemic for multi-drug resistant Plasmodium falciparum malaria, therapeutic responses were assessed in 1967 patients with uncomplicated falciparum malaria treated with 3 d of artesunate (total dose 12 mg/kg) plus mefloquine (total dose 25 mg/kg). The regimen was well tolerated and resulted in a rapid clinical response; within 48 h, 96% of patients were aparasitaemic and 94% were afebrile. After correcting for reinfections, the cure rate by day 42 ...

Expand abstract

Authors: Price, R; Nosten, F; Luxemburger, C; van Vugt, M; Phaipun, L

• Publication status: Published
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
• Volume: 91
• Issue: 5
• Pages: 574-577
• Publication date: 1997-01-01
• DOI: 10.1016/s0035-9203(97)90032-8
• EISSN: 1878-3503
• ISSN: 0035-9203
• Language: English
• Keywords: Risk Factors; Prospective Studies; Fever; Parasitemia; Malaria, Falciparum; Female; Sesquiterpenes; Middle Aged; Thailand; Male; Antimalarials; Child, Preschool; Child; Infant; Aged; Recurrence; Mefloquine; Endemic Diseases; Artemisinins; Follow-Up Studies; Drug Resistance, Multiple; Drug Therapy, Combination; Adult; Treatment Outcome; Humans; Adolescent