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Adverse outcome of human islet-allogeneic blood interaction.

Abstract:

BACKGROUND: A report of inflammatory damage when islets come into contact with allogeneic blood prompted us to confirm the finding. METHODS: Fresh handpicked human islets were incubated in blood group matched, nonsensitized allogeneic blood. Destruction was quantified by assaying the supernatants for proinsulin release and by blood clot histology. The effect on global hemostasis was assessed by thromboelastography (TEG), and heparin-bonded tubing was used to assess the effect on blood cellul...

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Publication status:
Published

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Authors


Horton, PJ More by this author
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Journal:
Transplantation
Volume:
75
Issue:
8
Pages:
1317-1322
Publication date:
2003-04-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:583b64b3-aa0f-497f-abf7-3cee23216294
Source identifiers:
141682
Local pid:
pubs:141682

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