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Journal article

Pathway utilization in response to a site-specific DNA double-strand break in fission yeast.

Abstract:

We have examined the genetic requirements for efficient repair of a site-specific DNA double-strand break (DSB) in Schizosaccharomyces pombe. Tech nology was developed in which a unique DSB could be generated in a non-essential minichromosome, Ch(16), using the Saccharomyces cerevisiae HO-endonuclease and its target site, MATa. DSB repair in this context was predominantly through interchromosomal gene conversion. We found that the homologous recombination (HR) genes rhp51(+), rad22A(+), rad32...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/cdg119

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Journal:
EMBO journal
Volume:
22
Issue:
6
Pages:
1419-1430
Publication date:
2003-03-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
131079

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