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De novo production of diverse intracellular antibody libraries.

Abstract:

Many therapeutic targets are intracellular proteins and molecules designed to interact with them must effectively bind to their target inside the cell. Intracellular antibodies (intrabodies) recognise and bind to proteins in cells and various methods have been developed to produce such molecules. Intracellular antibody capture (IAC) is based on a genetic screening approach and is a facile methodology with which effective intracellular antibodies can be obtained. During the development of the ...

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Publisher copy:
10.1093/nar/gng023

Authors


Forster, A More by this author
Lobato, MN More by this author
Rabbitts, TH More by this author
Journal:
Nucleic acids research
Volume:
31
Issue:
5
Pages:
e23
Publication date:
2003-03-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:583b0bf7-bbbe-4674-bcb5-02a71f4cc2e6
Source identifiers:
324287
Local pid:
pubs:324287

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