The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus.

Journal article

It has long been known that very acidic conditions can be found in degenerate discs. The effect of these acid conditions on matrix turnover are, however, unknown. This study aimed to examine the effect of acidity on production of matrix components and on agents which break down the matrix in order to gain insight into the effect of pathological values of pH on matrix turnover. Cells were isolated from the nucleus of bovine discs and from bovine articular cartilage, embedded in alginate beads ...

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Authors: Razaq, S; Wilkins, R; Urban, J

• Publication status: Published
• Journal: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
• Volume: 12
• Issue: 4
• Pages: 341-349
• Publication date: 2003-08-01
• DOI: 10.1007/s00586-003-0582-3
• EISSN: 1432-0932
• ISSN: 0940-6719
• Language: English
• Keywords: Cells, Cultured; Cattle; Hydrogen-Ion Concentration; Matrix Metalloproteinases; Extracellular Matrix; Intervertebral Disc; Glycosaminoglycans; Cartilage, Articular; Animals; Tissue Inhibitor of Metalloproteinases; Chondrocytes