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Demonstration of A-currents in pancreatic islet cells.

Abstract:

Voltage-activated K+ currents resistant to TEA but blockable by 4-AP were recorded from mouse pancreatic islet cells. These currents first become observable during depolarizations to voltages more positive than -40 mV, reaching a peak amplitude of 120 +/- 34 pA at +6 mV (n = 4), display rapid turn on (tau = 3.3 +/- 1.1 ms at +6 mV) and inactivate completely within 250 ms (tau = 65 +/- 5 at +6 mV). The current is subject to steady-state inactivation. The midpoint (Vh) of the inactivation curve...

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Publication status:
Published

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Publisher copy:
10.1007/bf00584497

Authors


Bokvist, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Pflugers Archiv : European journal of physiology
Volume:
413
Issue:
4
Pages:
441-443
Publication date:
1989-02-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:58399d28-6dcb-46ec-961c-c037c69daad6
Source identifiers:
10517
Local pid:
pubs:10517

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