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Journal article

Development and validation of a 28-gene hypoxia-related prognostic signature for localized prostate cancer

Abstract:

Background

Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer.

Method

Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ebiom.2018.04.019

Authors


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Role:
Author
ORCID:
0000-0002-8724-7051
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Prostate Cancer UK More from this funder
University of Manchester More from this funder
Canadian Institutes of Health Research More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
EBioMedicine Journal website
Volume:
31
Pages:
182-189
Publication date:
2018-04-23
Acceptance date:
2018-04-20
DOI:
EISSN:
2352-3964
Pubs id:
pubs:853104
URN:
uri:58318f69-a93a-4979-bbb6-e6db3bd79e3f
UUID:
uuid:58318f69-a93a-4979-bbb6-e6db3bd79e3f
Local pid:
pubs:853104

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