Journal article icon

Journal article

Divergent polo box domains underpin the unique kinetoplastid kinetochore

Abstract:

Kinetochores are macromolecular machines that drive eukaryotic chromosome segregation by interacting with centromeric DNA and spindle microtubules. While most eukaryotes possess conventional kinetochore proteins, evolutionarily-distant kinetoplastid species have unconventional kinetochore proteins, composed of at least 19 proteins (KKT1–19). Polo-like kinase (PLK) is not a structural kinetochore component in either system. Here we report the identification of an additional kinetochore protein...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1098/rsob.150206

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More from this funder
Funding agency for:
Akiyoshi, B
More from this funder
Funding agency for:
Akiyoshi, B
Publisher:
The Royal Society Publisher's website
Journal:
Open Biology Journal website
Publication date:
2016-03-16
DOI:
ISSN:
2046-2441
URN:
uuid:581750bc-8606-4973-bfe6-221764034ff9
Source identifiers:
605640
Local pid:
pubs:605640

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP