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Population pharmacokinetic properties of Piperaquine in Falciparum Malaria: an individual participant data-level meta-analysis

Abstract:

Background: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment of uncomplicated P.falciparum malaria, but ACT resistance is spreading across Southeast Asia. Dihydroartemisinin-piperaquine is one of the five ACTs currently recommended by the World Health Organization. Previous studies suggest that young children (<5 years) with malaria are under-dosed. The aim of the following study utilised a population-based pharmacokinetic approach to optimise the an...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1002212

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Department:
Oxford, MSD, NDM, Tropical Medicine
Workman, L More by this author
Edstein, MD More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Publication date:
2017-01-10
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:663645
URN:
uri:58174bed-d11f-4593-9a71-d1799f51e421
UUID:
uuid:58174bed-d11f-4593-9a71-d1799f51e421
Local pid:
pubs:663645

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