Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis
Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment, however a third of patients fail to achieve therapeutic responses. Unexpectedly, studies in murine and human arthritis have indicated that anti-TNF treatment can increase circulating Th17 cells, but the relationship to treatment response is unclear. To identify immune correlates of anti-TNF treatment response, we conducted a longitudinal study using clinical, ultrasound and T-cell assessments.
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- © 2016 Hull et al.licensee BioMed Central. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
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