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Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis

Abstract:

Background
Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment, however a third of patients fail to achieve therapeutic responses. Unexpectedly, studies in murine and human arthritis have indicated that anti-TNF treatment can increase circulating Th17 cells, but the relationship to treatment response is unclear. To identify immune correlates of anti-TNF treatment response, we conducted a longitudinal study using clinical, ultrasound and T-cell assessments.

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s13075-016-1197-5

Authors


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Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Department:
Oxford, MSD, NDORMS, KIR
Role:
Author
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Arthritis Research UK More from this funder
National Institute of Health Research More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Arthritis Research and Therapy Journal website
Publication date:
2016-12-23
Acceptance date:
2016-11-26
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
Pubs id:
pubs:661837
URN:
uri:58048d5c-5b23-460c-979d-a3e5bdf769c5
UUID:
uuid:58048d5c-5b23-460c-979d-a3e5bdf769c5
Local pid:
pubs:661837

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