- Abstract:
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Background
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Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment, however a third of patients fail to achieve therapeutic responses. Unexpectedly, studies in murine and human arthritis have indicated that anti-TNF treatment can increase circulating Th17 cells, but the relationship to treatment response is unclear. To identify immune correlates of anti-TNF treatment response, we conducted a longitudinal study using clinical, ultrasound and T-cell assessments.
... - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 1.2MB)
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- Publisher copy:
- 10.1186/s13075-016-1197-5
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- Publisher:
- BioMed Central Publisher's website
- Journal:
- Arthritis Research and Therapy Journal website
- Publication date:
- 2016-12-23
- Acceptance date:
- 2016-11-26
- DOI:
- EISSN:
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1478-6362
- ISSN:
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1478-6354
- Pubs id:
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pubs:661837
- URN:
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uri:58048d5c-5b23-460c-979d-a3e5bdf769c5
- UUID:
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uuid:58048d5c-5b23-460c-979d-a3e5bdf769c5
- Local pid:
- pubs:661837
- Copyright holder:
- Hull et al.
- Copyright date:
- 2016
- Notes:
- © 2016 Hull et al.licensee BioMed Central. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
Journal article
Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis
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Arthritis Research UK
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National Institute of Health Research
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