Journal article
Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis
- Abstract:
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Background
Expand abstract
Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment, however a third of patients fail to achieve therapeutic responses. Unexpectedly, studies in murine and human arthritis have indicated that anti-TNF treatment can increase circulating Th17 cells, but the relationship to treatment response is unclear. To identify immune correlates of anti-TNF treatment response, we conducted a longitudinal study using clinical, ultrasound and T-cell assessments.
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.2MB)
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- Publisher copy:
- 10.1186/s13075-016-1197-5
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Authors
Funding
National Institute of Health Research
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Arthritis Research UK
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Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Arthritis Research and Therapy Journal website
- Publication date:
- 2016-12-23
- Acceptance date:
- 2016-11-26
- DOI:
- EISSN:
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1478-6362
- ISSN:
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1478-6354
- Source identifiers:
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661837
Item Description
- Keywords:
- Pubs id:
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pubs:661837
- UUID:
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uuid:58048d5c-5b23-460c-979d-a3e5bdf769c5
- Local pid:
- pubs:661837
- Deposit date:
- 2016-11-28
Terms of use
- Copyright holder:
- Hull et al
- Copyright date:
- 2016
- Notes:
- © 2016 Hull et al.licensee BioMed Central. Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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