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Memory encoding and dopamine in the aging brain: a psychopharmacological neuroimaging study.

Abstract:

Normal aging brings with it changes in dopaminergic and memory functions. However, little is known about how these 2 changes are related. In this study, we identify a link between dopamine, episodic memory networks, and aging, using pharmacological functional magnetic resonance imaging. Young and older adults received a D2-like agonist (Bromocriptine, 1.25 mg), a D2-like antagonist (Sulpiride, 400 mg), and Placebo, in a double-blind crossover procedure. We observed group differences, during m...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/bhp139

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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Journal:
Cerebral cortex (New York, N.Y. : 1991)
Volume:
20
Issue:
3
Pages:
743-757
Publication date:
2010-03-01
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Source identifiers:
355965

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