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Journal article

The bromodomain interaction module.

Abstract:

ε-N-acetylation of lysine residues (K(ac)) is one of the most abundant post-translation modifications (PTMs) in the human proteome. In the nucleus, acetylation of histones has been linked to transcriptional activation of genes but the functional consequences of most acetylation events and proteins recruited to these sites remains largely unknown. Bromodomains (BRDs) are small helical interaction modules that specifically recognize acetylation sites in proteins. BRDs have recently emerged as i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Role:
Author
Journal:
FEBS letters
Volume:
586
Issue:
17
Pages:
2692-2704
Publication date:
2012-08-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:57f52244-1a4d-4493-8510-d45afc924825
Source identifiers:
333955
Local pid:
pubs:333955

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