Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress.

Journal article

Multiple KH-domain proteins, collectively known as vigilins, are evolutionarily highly conserved proteins that are present in eukaryotic organisms from yeast to metazoa. Proposed roles for vigilins include chromosome segregation, messenger RNA (mRNA) metabolism, translation and tRNA transport. As a step toward understanding its biological function, we have identified the fission yeast vigilin, designated Vgl1, and have investigated its role in cellular response to environmental stress. Unlike...

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Authors: Wen, W; Stevenson, A; Wang, C; Chen, H; Kearsey, S

• Publication status: Published
• Journal: Nucleic acids research
• Volume: 38
• Issue: 19
• Pages: 6555-6566
• Publication date: 2010-10-01
• DOI: 10.1093/nar/gkq555
• EISSN: 1362-4962
• ISSN: 0305-1048
• Language: English
• Keywords: Microtubules; RNA-Binding Proteins; Hot Temperature; Protein Structure, Tertiary; Schizosaccharomyces pombe Proteins; Saccharomyces cerevisiae Proteins; Mutation; Cytoplasmic Granules; Schizosaccharomyces; Polyploidy; Gene Expression; Stress, Physiological; Endoplasmic Reticulum