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Extracellular vesicles from early stage Plasmodium falciparum‐infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

Abstract:

Pathogens can release extracellular vesicles (EVs) for cell–cell communication and host modulation. EVs from Plasmodium falciparum, the deadliest malaria parasite species, can transfer drug resistance genes between parasites. EVs from late‐stage parasite‐infected RBC (iRBC‐EVs) are immunostimulatory and affect endothelial cell permeability, but little is known about EVs from early stage iRBC. We detected the parasite virulence factor PfEMP1, which is responsible for iRBC adherence and a major...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/cmi.12822

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
RDM - Investigative Medicine Division
ORCID:
0000-0002-8396-1354
Garnham, AL More by this author
Sisquella, X More by this author
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Publisher:
John Wiley and Sons, Ltd. Publisher's website
Journal:
Cellular Microbiology Journal website
Volume:
20
Issue:
5
Publication date:
2018-01-18
Acceptance date:
2018-01-11
DOI:
EISSN:
1462-5822
ISSN:
1462-5814
Pubs id:
pubs:826919
URN:
uri:57c0c8e4-55e2-4860-814f-fea1b403e16a
UUID:
uuid:57c0c8e4-55e2-4860-814f-fea1b403e16a
Local pid:
pubs:826919

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