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Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters.

Abstract:

Transcriptional termination by RNA polymerase II at the 3' end of genes encoding poly(A)+ mRNAs is thought to require two distinct cis-active elements: a functional poly(A) signal and a downstream transcriptional pause site. An important requirement for efficient termination is to prevent transcriptional interference of downstream-located promoters. We have therefore investigated whether these two elements, individually or in combination, can prevent transcriptional interference of RNA polyme...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
EMBO journal
Volume:
12
Issue:
6
Pages:
2539-2548
Publication date:
1993-06-01
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
7305
Language:
English
Keywords:
Pubs id:
pubs:7305
UUID:
uuid:57bca2ae-cbae-40a7-b4ec-d4f2689fec46
Local pid:
pubs:7305
Deposit date:
2012-12-19

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