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Journal article

Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.

Abstract:

OBJECTIVES: This study sought to determine the effects of a p38 mitogen-activated protein kinase inhibitor, losmapimod, on vascular inflammation, by (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography imaging. BACKGROUND: The p38 mitogen-activated protein kinase cascade plays an important role in the initiation and progression of inflammatory diseases, including atherosclerosis. METHODS: Patients with atherosclerosis on stable statin therapy (n = 99) were randomize...

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Publication status:
Published

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Publisher copy:
10.1016/j.jcmg.2012.02.016

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Journal:
JACC. Cardiovascular imaging
Volume:
5
Issue:
9
Pages:
911-922
Publication date:
2012-09-05
DOI:
EISSN:
1876-7591
ISSN:
1936-878X
URN:
uuid:57b6d166-c91d-40cd-a951-00994a26d455
Source identifiers:
352772
Local pid:
pubs:352772

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