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CoQ10 fails to protect brain against focal and global ischemia in rats.

Abstract:

OBJECTIVE: Release of oxygen free radicals occurs following cerebral ischemia. Studies show that oxygen free radicals mediate ischemic brain injury. CoQ10 is a potent free radical scavenger and may offset brain injury associated with reperfusion. We tested exogeneous CoQ10 as a neuroprotectant in rats following both global and focal ischemic insults. METHODS: Rats were subjected to either 4-vessel occlusion ischemia (4-VO, 10 min occlusion, 7-day survival) or middle cerebral artery occlusion ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
Brain research
Volume:
877
Issue:
1
Pages:
7-11
Publication date:
2000-09-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:579ff819-ea54-41ab-822e-e14acc60b288
Source identifiers:
79160
Local pid:
pubs:79160

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