Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death?

Journal article

Most deaths in the first 30 days after cardiac transplantation are due to failure of the donor heart, often with the clinical picture of right ventricular failure. Indeed, there is a significant reduction in contractility of the human donor heart and loss of contractile reserve before and soon after transplantation. This myocardial insult appears in association with brain death in the donor and follows a "catecholamine storm" associated with a rapidly rising intracranial pressure. Microscopy ...

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Authors: Berman, M; Ali, A; Ashley, E; Freed, D; Clarke, K

• Publication status: Published
• Journal: Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• Volume: 29
• Issue: 9
• Pages: 957-965
• Publication date: 2010-09-01
• DOI: 10.1016/j.healun.2010.04.008
• EISSN: 1557-3117
• ISSN: 1053-2498
• Language: English
• Keywords: Tissue Donors; Ventricular Dysfunction; Catecholamines; Humans; Heart Ventricles; Brain Death; Organ Size; Heart Failure; Ventricular Dysfunction, Left; Electrocardiography; Myocardial Stunning; Ventricular Dysfunction, Right; Takotsubo Cardiomyopathy; Heart Transplantation; Stroke Volume