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The Abca4-/- mouse model of Stargardt disease – phenotype and therapeutic strategies

Abstract:

Stargardt disease is caused by mutations in the ABCA4 gene and is probably the commonest inherited cause for retinal degeneration in youth with progressive visual deterioration. The Abca4-/- mouse is an animal model mimicking certain aspects of the human disease, including an accumulation of autofluorescent lipofuscin in the retinal pigment epithelium (RPE). The model is therefore ideally suited for preclinical investigation of novel treatment approaches for Stargardt disease.

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Institution:
University of Oxford
Research group:
Professor Robert MacLaren
Oxford college:
Merton College
Department:
Medical Sciences Division - Ophthalmology
Role:
Author

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Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral

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