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Journal article

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

Abstract:

Background: The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and episodes of clinical malaria. Methods: Using data from 5,144 participants in nine phase 2 trials, we explore predictors of vaccine immunogenicity (anti-CSP antibody titres), decay in antibody titres, and the association between antibody titres and clinical outcomes. We use empiri...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12916-014-0117-2

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Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC Medicine Journal website
Volume:
12
Issue:
1
Pages:
117-117
Publication date:
2014-07-10
DOI:
EISSN:
1741-7015
ISSN:
1741-7015
URN:
uuid:57899827-861d-4c92-8af6-c0442d29b9fd
Source identifiers:
481288
Local pid:
pubs:481288

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