- Abstract:
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Background: The RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and episodes of clinical malaria. Methods: Using data from 5,144 participants in nine phase 2 trials, we explore predictors of vaccine immunogenicity (anti-CSP antibody titres), decay in antibody titres, and the association between antibody titres and clinical outcomes. We use empiri...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer Reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.8MB)
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- Publisher copy:
- 10.1186/s12916-014-0117-2
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- Publisher:
- BioMed Central Ltd. Publisher's website
- Journal:
- BMC Medicine Journal website
- Volume:
- 12
- Issue:
- 1
- Pages:
- 117-117
- Publication date:
- 2014-07-10
- DOI:
- EISSN:
-
1741-7015
- ISSN:
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1741-7015
- URN:
-
uuid:57899827-861d-4c92-8af6-c0442d29b9fd
- Source identifiers:
-
481288
- Local pid:
- pubs:481288
- Language:
- English
- Keywords:
- Copyright holder:
- White et al.
- Copyright date:
- 2014
- Notes:
- © 2014 White et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Journal article
A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine
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