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Is aberrant affective cognition an endophenotype for affective disorders? A monozygotic twin study

Abstract:

Background

Identification of endophenotypes can improve prevention, detection and development of new treatments. We therefore investigated whether aberrant affective cognition constitutes an endophenotype for affective disorders by being present in monozygotic (MZ) twins with unipolar or bipolar disorder in partial remission (i.e. affected) and their unaffected co-twins (i.e. high-risk) relative to twins with no family history of affective disorder (i.e. low-risk).

Method...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1017/S0033291718001642

Authors


Meluken, I More by this author
Ottesen, NM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Scheike, T More by this author
Kessing, LV More by this author
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Lundbeck Foundation More from this funder
Hørslev Foundation More from this funder
Weimann Foundation More from this funder
Publisher:
Cambridge University Press Publisher's website
Journal:
Psychological Medicine Journal website
Volume:
49
Issue:
6
Pages:
987-996
Publication date:
2018-07-02
Acceptance date:
2018-05-29
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
Pubs id:
pubs:859454
URN:
uri:578995d6-9c5f-40aa-ae37-44caf61bf26e
UUID:
uuid:578995d6-9c5f-40aa-ae37-44caf61bf26e
Local pid:
pubs:859454

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