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The structure of HIV-1 Rev filaments suggests a bilateral model for Rev-RRE assembly.

Abstract:

HIV-1 Rev protein mediates the nuclear export of viral RNA genomes. To do so, Rev oligomerizes cooperatively onto an RNA motif, the Rev-response element (RRE), forming a complex that engages with the host nuclear export machinery. To better understand Rev oligomerization, we determined four crystal structures of Rev N-terminal domain dimers, which show that they can pivot about their dyad axis, giving crossing-angles of 90° to 140° . I...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manucscript

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Publisher copy:
10.1016/j.str.2016.04.015

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More from this funder
Funding agency for:
Grimes, JM
National Institutes of Health More from this funder
National Institute for Arthritis and Skin Diseases More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Structure Journal website
Volume:
24
Issue:
7
Pages:
1068-1080
Publication date:
2016-06-05
Acceptance date:
2016-04-25
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
URN:
uuid:57807989-58fa-4ce7-b6a1-18152f9baefc
Source identifiers:
628806
Local pid:
pubs:628806
Language:
English

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