Journal article icon

Journal article

Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype.

Abstract:

Tumor-associated macrophages (TAM) may have tumor-promoting activity, but it is not clear how their phenotype is achieved. In this study, we demonstrate that ovarian cancer cells switch cocultured macrophages to a phenotype similar to that found in ovarian tumors. Tumor cells caused dynamic changes in macrophage cytokine, chemokine, and matrix metalloprotease mRNA, and protein-inducing mediators that are found in human cancer. Macrophage mannose, mannose receptor, and scavenger receptors (SR-...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.4049/jimmunol.176.8.5023

Authors


Hagemann, T More by this author
Expand authors...
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
176
Issue:
8
Pages:
5023-5032
Publication date:
2006-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:577f2130-11cc-4ad9-94e8-653b6508b7c4
Source identifiers:
2125
Local pid:
pubs:2125

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP