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Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype.

Abstract:

Tumor-associated macrophages (TAM) may have tumor-promoting activity, but it is not clear how their phenotype is achieved. In this study, we demonstrate that ovarian cancer cells switch cocultured macrophages to a phenotype similar to that found in ovarian tumors. Tumor cells caused dynamic changes in macrophage cytokine, chemokine, and matrix metalloprotease mRNA, and protein-inducing mediators that are found in human cancer. Macrophage mannose, mannose receptor, and scavenger receptors (SR-...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.176.8.5023

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Journal:
Journal of Immunology
Volume:
176
Issue:
8
Pages:
5023-5032
Publication date:
2006-04-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
2125

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