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Thesis

Ligand-macromolecule interactions

Abstract:

The optimisation of ligand-macromolecule interactions is fundamental to the design of therapeutic agents. The GRID method is a procedure for determining energetically favourable ligand binding sites on molecules of known structure using an empirical energy potential. In this thesis, it has been extended, tested, and then applied to the design of anti-influenza agents.

In the GRID method, the energy of a hydrogen-bond is determined by a function which is dependent on the length of t...

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Institution:
University of Oxford
Department:
Life and Environmental Sciences Division
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
1988
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
602835269
URN:
uuid:576ce119-6a93-4eb0-a7e4-1f2513736dbd
Local pid:
td:602835269

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