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Accurate quantification of modified cyclic peptides without the need for authentic standards

Abstract:

There is a growing interest in the use of cyclic peptides as therapeutics, but their efficient production is often the bottleneck in taking them forward in the development pipeline. We have recently developed a method to synthesise azole-containing cyclic peptides using enzymes derived from different cyanobactin biosynthetic pathways. Accurate quantification is crucial for calculation of the reaction yield and for the downstream biological testing of the products. In this study, we demonstrat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tet.2016.11.040

Authors


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Funding agency for:
Raab, A
Grant:
312184
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Funding agency for:
Houssen, W
Grant:
RPG 2012-504
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Funding agency for:
Thomas, L
Grant:
RPG 2012-504
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Publisher:
Elsevier Publisher's website
Journal:
Tetrahedron Journal website
Volume:
72
Issue:
52
Pages:
8603-8609
Publication date:
2016-11-16
Acceptance date:
2016-11-14
DOI:
EISSN:
1464-5416
ISSN:
0040-4020
Source identifiers:
699668
Keywords:
Pubs id:
pubs:699668
UUID:
uuid:576c7af0-50c3-48f7-b851-8e629e353bf6
Local pid:
pubs:699668
Deposit date:
2017-07-24

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