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Effects of ACE inhibition and beta-receptor blockade on energy metabolism in rats postmyocardial infarction.

Abstract:

Chronic treatment with beta-receptor blockers or angiotensin-converting enzyme (ACE) inhibitors in heart failure can reduce mortality and improve left ventricular function, but the mechanisms involved in their beneficial action remain to be fully defined. Our hypothesis was that these agents prevent the derangement of cardiac energy metabolism. Rats were subjected to myocardial infarction (MI) or sham operation. Thereafter, animals were treated with bisoprolol, captopril, or remained untreate...

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Journal:
The American journal of physiology
Volume:
277
Issue:
6 Pt 2
Pages:
H2167-H2175
Publication date:
1999-12-05
ISSN:
0002-9513
URN:
uuid:576024e0-d130-4afe-8c43-281e4a74612b
Source identifiers:
441366
Local pid:
pubs:441366

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