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Angiotensin regulation of amygdala response to threat in high-trait-anxiety individuals

Abstract:
Background The antihypertensive drug losartan has been shown to improve memory in humans as well as learning and fear extinction in rodent models, highlighting its potential to have similar synergistic effects on exposure-based cognitive behavioral therapy for anxiety disorders. This study investigated the effect of losartan on neural correlates of processing threat versus safety stimuli in highly anxious individuals to identify potential pathways of how the drug might facili... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.bpsc.2018.05.007

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
ORCID:
0000-0001-9108-3144
Klein Breteler, J More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Ressler, KJ More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Journal website
Volume:
3
Issue:
10
Pages:
826-835
Publication date:
2018-06-05
Acceptance date:
2018-05-15
DOI:
EISSN:
2451-9022
ISSN:
2451-9030
Pubs id:
pubs:858788
URN:
uri:574986a6-939f-4859-8f0b-6a602811b697
UUID:
uuid:574986a6-939f-4859-8f0b-6a602811b697
Local pid:
pubs:858788

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