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BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.

Abstract:

The tumor suppressor gene product BRCA1 is a component of the RNA polymerase II (pol II) holoenzyme that is involved, through binding to various regulatory proteins, in either activation or repression of transcription. Using a yeast two-hybrid screen, we have identified a human zinc-finger-containing protein NUFIP that interacts with BRCA1. The ubiquitous, stably expressed, nuclear protein NUFIP specifically stimulates activator-independent pol II transcription in vitro and in vivo. Immunodep...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1207684

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Oncogene
Volume:
23
Issue:
31
Pages:
5316-5329
Publication date:
2004-07-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:5746fb32-d842-4aea-8e86-5ee63323d02b
Source identifiers:
15659
Local pid:
pubs:15659

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