- Abstract:
-
The tumor suppressor gene product BRCA1 is a component of the RNA polymerase II (pol II) holoenzyme that is involved, through binding to various regulatory proteins, in either activation or repression of transcription. Using a yeast two-hybrid screen, we have identified a human zinc-finger-containing protein NUFIP that interacts with BRCA1. The ubiquitous, stably expressed, nuclear protein NUFIP specifically stimulates activator-independent pol II transcription in vitro and in vivo. Immunodep...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/sj.onc.1207684
-
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- Journal:
- Oncogene
- Volume:
- 23
- Issue:
- 31
- Pages:
- 5316-5329
- Publication date:
- 2004-07-05
- DOI:
- EISSN:
-
1476-5594
- ISSN:
-
0950-9232
- URN:
-
uuid:5746fb32-d842-4aea-8e86-5ee63323d02b
- Source identifiers:
-
15659
- Local pid:
- pubs:15659
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
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