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Measurement of phosphatidylserine exposure during storage of platelet concentrates using the novel probe lactadherin: a comparison study with annexin V.

Abstract:

BACKGROUND: Annexin V binding to platelets (PLTs) is considered the gold standard for monitoring phosphatidylserine (PS) exposure. However, recent comparison of annexin V with the new calcium-independent PS probe lactadherin revealed that annexin V requires a certain threshold of PS exposure (2%-8%) for binding to occur. The aim of this study was to compare annexin V and lactadherin labeling of PLTs in PLT concentrates (PCs). STUDY DESIGN AND METHODS: Optimal labeling conditions for lactadhe...

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Publication status:
Published

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Authors


Albanyan, AM More by this author
Murphy, MF More by this author
Rasmussen, JT More by this author
Heegaard, CW More by this author
Harrison, P More by this author
Journal:
Transfusion
Volume:
49
Issue:
1
Pages:
99-107
Publication date:
2009-01-05
DOI:
EISSN:
1537-2995
ISSN:
0041-1132
URN:
uuid:57425a5c-73f6-491e-9dbc-83b199bd51c8
Source identifiers:
191186
Local pid:
pubs:191186

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