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Journal article

Tolerance in TCR/cognate antigen double-transgenic mice mediated by incomplete thymic deletion and peripheral receptor downregulation.

Abstract:

Influenza nucleoprotein (NP)-specific T-cell receptor transgenic mice (F5) were crossed with transgenic mice expressing the cognate antigenic protein under the control of the H-2Kb promoter. Double-transgenic mice show negative selection of thymocytes at the CD4+8+TCRlo to CD4+8+TCRhi transition stage. A few CD8+ T cells, however, escape clonal deletion, and in the peripheral lymphoid organs of these mice, they exhibit low levels of the transgenic receptor and upregulated levels of the CD44 m...

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Publication status:
Published

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Publisher copy:
10.1155/1995/54219

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Journal:
Developmental immunology
Volume:
4
Issue:
4
Pages:
299-315
Publication date:
1996-01-01
DOI:
ISSN:
1044-6672
URN:
uuid:57419a48-655b-4f3e-888e-47ee98fbe981
Source identifiers:
72154
Local pid:
pubs:72154

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